The NFL is finally back after a long summer hiatus.
The NFL resumes with 16 games this week, starting with an AFC Championship Game rematch between the Kansas City Chiefs and Baltimore Ravens on Thursday, Sept. 5.
The Chiefs will get their championship rings after walking off the San Francisco 49ers in overtime of Super Bowl LVIII in February.
Following the Thursday Night Football contest, the first-ever NFL game played in South America takes place on Friday, Sept. 6, as the Philadelphia Eagles battle the Green Bay Packers in São Paulo, Brazil.
Week 1 heats up with 13 games on Sunday before winding down with a Monday Night Football clash between the 49ers and New York Jets.
With so many NFL games on the docket, there will be endless betting opportunities available this weekend at our recommended NFL betting sites, all of which have special NFL promos to begin the season.
NFL Week 1 Preview
Click on an individual game below to see all the odds, lines, picks, predictions and best bets.
Thursday, Sept. 5
Friday, Sept. 6
Sunday, Sept. 8
- Carolina Panthers vs. New Orleans Saints, 1 p.m. ET
- Minnesota Vikings vs. New York Giants, 1 p.m. ET
- New England Patriots vs. Cincinnati Bengals, 1 p.m. ET.
- Pittsburgh Steelers vs. Atlanta Falcons, 1 p.m. ET
- Houston Texans vs. Indianapolis Colts, 1 p.m. ET
- Arizona Cardinals vs. Buffalo Bills, 1 p.m. ET
- Tennessee Titans vs. Chicago Bears, 1 p.m. ET
- Jacksonville Jaguars vs. Miami Dolphins, 1 p.m. ET
- Denver Broncos vs. Seattle Seahawks, 4:05 p.m. ET
- Las Vegas Raiders vs. Los Angeles Chargers, 4:05 p.m. ET
- Dallas Cowboys vs. Cleveland Browns, 4:25 p.m. ET
- Washington Commanders vs. Tampa Bay Buccaneers, 4:25 p.m. ET
- Los Angeles Rams vs. Detroit Lions, 8:20 p.m. ET
Monday, Sept. 9
Note: Game odds and lines can vary based on the NFL betting app and are subject to change. Betting on the NFL can cause problems for some players. Always gamble responsibly by setting a budget and understanding the vig (house edge).