The Dallas Cowboys (3-3) take on the San Francisco 49ers (3-4) on Sunday Night Football. Kickoff from Levi’s Stadium is set for 8:20 p.m. ET (NBC). Let’s analyze BetMGM Sportsbook’s NFL odds around the Cowboys vs. 49ers odds, and make our expert NFL picks and predictions.
The Cowboys were punked in a 47-9 home defeat to the Detroit Lions before their bye last week. Dallas is now 0-3 at home and 3-0 on the road. QB Dak Prescott was 17-for-33 for 178 yards, 0 TDs and 2 INTs. WR CeeDee Lamb did what he could with 7 catches for 89 yards on 14 targets.
The Niners were upended 28-18 at home by the Kansas City Chiefs last week as 2-point favorites. QB Brock Purdy threw 3 picks, but he was able to run in 2 touchdowns. They also lost star WR Brandon Aiyuk (knee) to a torn ACL and MCL for the season. WR Deebo Samuel (wrist, illness) and TE George Kittle (foot) are both questionable this week, and the 49ers’ options are wearing thin.
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Cowboys at 49ers odds
Provided by BetMGM Sportsbook; access USA TODAY Sports Scores and Sports Betting Odds hub for a full list of NFL odds. Lines last updated at 1:56 a.m. ET.
- Moneyline (ML): Cowboys +180 (bet $100 to win $180) | 49ers -225 (bet $225 to win $100)
- Against the spread (ATS): Cowboys +4.5 (-110) | 49ers -4.5 (-110)
- Over/Under (O/U): 47 (O: -110 | U: -110)
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Cowboys at 49ers key injuries
Cowboys
- CB DaRon Bland (foot) out
- LB Eric Kendricks (shoulder) questionable
- DE Micah Parsons (ankle) out
- DT Jordan Phillips (wrist) out
- LB Nick Vigil (foot) questionable
49ers
- WR Brandon Aiyuk (knee) out
- WR Jauan Jennings (hip) out
- TE George Kittle (foot) probable
- CB Deommodore Lenoir (illness) questionable
- RB Christian McCaffrey (Achilles) out
- PK Jake Moody (ankle) out
- WR Deebo Samuel (wrist, illness) probable
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Cowboys at 49ers picks and predictions
Prediction
49ers 24, Cowboys 17
Moneyline
The Cowboys are reeling on defense without DE Demarcus Lawrence (foot) and Parsons. Their pass rush has been awful. As a defensive team, they’re the worst in fantasy over the last 5 weeks and have just 7 sacks in that span. The Niners have won 3 matchups in a row, and the Cowboys haven’t defeated them since 2020.
The Niners should win this game, but they’re nowhere near worth dropping -225 on.
Instead, I’m rolling with BROCK PURDY OVER 18.5 RUSHING YARDS (-110). He has hit this number 3 games in a row.
Against the spread
I’m rolling with 49ERS -4.5 (-110) here. They’ve defeated the Cowboys by 5+ points in each of their 3 consecutive victories over them. The lack of a Dallas pass rush should give Purdy the time to pick them apart.
Over/Under
This number looks a little high at first glance.
The Under has cashed in 2 of the last 3 meetings. It has cashed in 2 of the last 3 Niners games and 2 of the last 3 Cowboys games.
Take the UNDER 47 (-110).
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