The NFL’s longest losing streak is on the line when the New Orleans Saints take on the Carolina Panthers. The New York Jets’ win on Thursday Night Football means whichever side finds itself on the losing end of the latest NFC South clash will own the league’s longest skid. Which side will climb out of the hole it’s currently in?

Bank of America Stadium in Charlotte, North Carolina, hosts this Sunday afternoon showdown. Kickoff is slated for noon CT and CBS will have the regional broadcast. Who are sportsbooks favoring in this clash?

New Orleans Saints vs. Carolina Panthers odds, pick, prediction

FanDuel Sportsbook lists the Saints as 7-point road favorites with an over/under of 43.5.

Let’s dive into the odds for the highly anticipated contest:

New Orleans Saints at Carolina Panthers

Time/TV: Noon CT (CBS)

Spread (via FanDuel Sportsbook): Saints -7

Total: 43.5

Moneyline: Saints -330, Panthers +265

Analysis: When was the last time a team on a league-leading six-game losing streak was favored on the road by a touchdown over a divisional opponent? I’m going to be honest, I’ve never seen it happen. Unfortunately for Carolina, it epitomizes the team’s struggles right now.

New Orleans gets a huge boost with the return of Derek Carr. While he won’t fix all of the team’s issues, he’ll at least be able to run the offense more efficiently than Jake Haener or Spencer Rattler.

The Saints pummeled the Panthers to start the season inside the Caesars Superdome, 47-10. That result undeniably played a factor in oddsmakers coming up with a line for this contest. I doubt they reach 57 total points again.

While I believe Carolina will fare better this time — unfortunately, you cannot find any sportsbook offering a spread of Panthers +37 — I don’t think the hosts have the horses to win outright. Carolina is a league-worst 1-7 against the spread, so I like New Orleans to get back to winning ways in enemy territory.

Prediction: Saints 23, Panthers 10 (Under 43.5)

Best bet: Saints -7 over Panthers (-110 at FanDuel Sportsbook)