The NFL Week 6 schedule kicks off Thursday with the 2-3 San Francisco 49ers on the road against the 3-2 Seattle Seahawks with an NFC West division lead on the line. We have more Sunday morning football from London featuring the Jacksonville Jaguars and the Chicago Bears, while the Sunday nightcap features the Cincinnati Bengals and New York Giants The week culminates with “Monday Night Football” from East Rutherford, New Jersey, in a rematch of the 2023 Week 1 MNF game between the Buffalo Bills and New York Jets in which Aaron Rodgers suffered his season-ending Achilles tear.

Here’s a look at all the Week 6 games. Football Power Index (FPI) by ESPN Analytics. Odds current as of publication time. For most current odds go to ESPN BET

MORE NFL BETTING CONTENT: Early picks for Week 6 | By the numbers: NFL point spreads tightest in Super Bowl era

San Francisco 49ers -3.5 vs. Seattle Seahawks
Thursday, 8:15 p.m. ET, Prime Video

Money Line: 49ers (-185) ; Seahawks (+155)
Total: 47.5; Opened: 46.5
FPI favorite: 49ers by 4.6, 61.9% to win outright

Jacksonville Jaguars vs. Chicago Bears -2.5
Sunday, 9:30 a.m. ET, NFL Net

Money Line: Jaguars (+115) ; Bears (-135)
Total: 44.5; Opened: 43.5
FPI favorite: Bears by 3.7, 59.1% to win outright

Indianapolis Colts -1 vs. Tennessee Titans
Sunday, 1 p.m. ET, CBS

Money Line: Colts (-115) ; Titans (-105)
Total: 42.5; Opened: 42.5
FPI favorite: Colts by 0.7, 52.7% to win outright

Cleveland Browns vs. Philadelphia Eagles -8.5
Sunday, 1 p.m. ET, Fox

Money Line: Browns (+340) ; Eagles (-425)
Total: 43.5; Opened: 43.5
FPI favorite: Eagles by 8, 69.7% to win outright

Arizona Cardinals vs. Green Bay Packers -5
Sunday, 1 p.m. ET, Fox

Money Line: Cardinals (+195) ; Packers (-230)
Total: 49.5; Opened: 49.5
FPI favorite: Packers by 4.4, 61.9% to win outright

Odds current as of publication time. For most current odds go to ESPN BET

Washington Commanders vs. Baltimore Ravens -6.5
Sunday, 1 p.m. ET, CBS

Money Line: Commanders (+240) ; Ravens (-290)
Total: 52.5; Opened: 51.5
FPI favorite: Ravens by 6, 64.4% to win outright

Tampa Bay Buccaneers -2.5 vs. New Orleans Saints
Sunday, 1 p.m. ET, Fox

Line movement: Opened Saints -2.5

Money Line: Buccaneers (-135) ; Saints (+115)
Total: 42.5; Opened: 45.5
FPI favorite: Saints by 2.1, 54.4% to win outright

Houston Texans -7 vs. New England Patriots
Sunday, 1 p.m. ET, CBS

Money Line: Texans (-320) ; Patriots (+260)
Total: 37.5; Opened: 38.5
FPI favorite: Texans by 7.5, 69% to win outright

Los Angeles Chargers -3 vs. Denver Broncos
Sunday, 4:05 p.m. ET, CBS

Money Line: Chargers (-155) ; Broncos (+135)
Total: 35.5; Opened: 36.5
FPI favorite: Chargers by 2, 54.5% to win outright

Pittsburgh Steelers -3 vs. Las Vegas Raiders
Sunday, 4:05 p.m. ET, CBS

Money Line: Steelers (-155) ; Raiders (+135)
Total: 36.5; Opened: 36.5
FPI favorite: Steelers by 2.5, 57.2% to win outright

Atlanta Falcons -6.5 vs. Carolina Panthers
Sunday, 4:25 p.m. ET, Fox

Line movement: Opened Falcons -4.5

Money Line: Falcons (-275) ; Panthers (+225)
Total: 47.5; Opened: 47.5
FPI favorite: Falcons by 5.2, 62.2% to win outright

Detroit Lions -3.5 vs. Dallas Cowboys
Sunday, 4:25 p.m. ET, Fox

Money Line: Lions (-170) ; Cowboys (+145)
Total: 52.5; Opened: 52.5
FPI favorite: Lions by 3, 57.4% to win outright

Cincinnati Bengals -3.5 vs. New York Giants
Sunday, 8:20 p.m. ET, NBC, Peacock

Money Line: Bengals (-175) ; Giants (+150)
Total: 48.5; Opened: 48.5
FPI favorite: Bengals by 4.1, 60.8% to win outright

Buffalo Bills -2.5 vs. New York Jets
Monday, 8:15 p.m. ET, ESPN

Money Line: Bills (-135) ; Jets (+115)
Total: 41.5; Opened: 41.5
FPI favorite: Bills by 2, 55.1% to win outright